Physical

How do you calculate vapor pressure & rotovap?

Antoine vapor pressure of a solvent, and the boiling point at each vacuum setpoint. The relationship used is log10(P[bar]) = A − B/(T[K] + C).

Worked example

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What you are given

  • Temperature: 25

Formula: log10(P[bar]) = A − B/(T[K] + C)

The working

  1. Antoine: log10(P) = A − B/(T + C) = 4.6543 − 1435.264/(298.15 − 64.848)
  2. Pressure: P = 0.0318 bar

Water at 25 °C: 31.8 mbar (23.8 mmHg)

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